ABSTRACT
Paenibacillus spp. are gram-positive, rod-shaped, facultative anaerobic bacteria found in nature and rarely cause diseases in humans. We report our experience with Paenibacillus-induced sepsis complicated with pneumatocele in a very low birth weight male infant with a gestational age of 29 weeks and 5 days and a birth weight of 1,380 g, who was born by cesarean section with because of preterm labor and premature rupture of membrane. On day 12 after admission, the patient presented oxygen desaturation without apnea and fever. We identified pleural effusion on chest radiography and diagnosed pneumatocele on low-dose chest computed tomography. An empirical antibiotic was administered to treat the infection. The patient's blood culture revealed gram-positive rods, and Paenibacillus spp. was identified using16s rRNA sequencing.
Subject(s)
Female , Humans , Infant , Male , Pregnancy , Apnea , Bacteria, Anaerobic , Birth Weight , Cesarean Section , Fever , Gestational Age , Gram-Positive Rods , Infant, Very Low Birth Weight , Membranes , Obstetric Labor, Premature , Oxygen , Paenibacillus , Pleural Effusion , Radiography , Rupture , Sepsis , ThoraxABSTRACT
PURPOSE: Of numerous health status indicators, those of neonate and peripartum encompass nation's maternal, birth, neonatal and infantile health level. The goal of this study was to investigate the changes during the past 50 years of neonatal and perinatal indicators in Korea. METHODS: We analyzed the changes of population, number of live births per year, crude birth rate (CBR), total fertility rate (TFR), incidence of low birth weight infant (LBWI) and preterm infants, neonatal mortality rate (NMR), infant mortality rate (IMR), perinatal mortality rate (PMR), and maternal mortality ratio (MMR) of Korea, and especially compared those indicators of Korea with those of other OECD nations during the past 50 years. RESULTS: Korea has accomplished a marked improvement in the above indicators during the past 50 years. The average index of OECD and Korean rank among 34 OECD nations in the above health indicators in 2010 are as follows: population 49,410,370 (36,285,235, 9th), CBR 9.4 (12.1, 4th), TFR 1.23 (1.75, 1st), LBWI incidence 5.0 (6.8, 6th), NMR 1.8 (2.9, 8th), IMR 3.2 (4.3, 10th), PMR 3.3 (6.0, 4th), MMR 15.7 (8.7, 29th). CONCLUSION: Birth rate of Korea was very low among OECD nations with relatively low LBWI incidence. It is inspiring that NR, IMR, and PMR were lower than the average. However, MMR was very higher than the average of OECD. The present review provides the neonatal and perinatal health indicators in Korea and it might be helpful to improve clinical practice and outcome in the future.
Subject(s)
Humans , Infant , Infant, Newborn , Birth Rate , Epidemiology , Health Status , Health Status Indicators , Incidence , Infant Mortality , Infant, Low Birth Weight , Infant, Premature , Korea , Live Birth , Maternal Mortality , Mortality , Parturition , Perinatal Mortality , Peripartum Period , Republic of Korea , Vital StatisticsABSTRACT
The genetic alterations of vitamin D receptor (VDR) are related with the growth of long bone. There were a lot of reports regarding an association of polymorphisms in the VDR promoter with many disorders, but not with idiopathic short stature (ISS). We investigated the association of them with ISS. A total of 50 subjects, including 29 ISS patients and 21 healthy controls with their heights within the normal range was recruited. We selected two single nucleotide polymorphisms (SNPs) from VDR promoter (rs11568820 at the Cdx-2 binding site upstream of exon 1e and rs4516035 at -1012 upstream of exon 1a) as candidates, respectively. In genotype analysis, the frequency of A/A genotype at the Cdx-2 binding site locus (rs11568820) upstream of exon 1e of VDR was decreased to 6.9% in ISS patients (28.6% in controls) (P = 0.027). The genetic variation at the Cdx-2 binding site of VDR promoter can be a contributing factor of growth of height.